Human Papillomavirus
Studies from University of Iowa, Medical Department reveal new findings on human papillomavirus
Published in Gene Therapy Weekly, December 25th, 2008
"A conserved E8 boolean AND E2 spliced mRNA is detected in keratinocytes transfected with human papillomavirus type 16 (HPV-16) plasmid DNA. Expression of HPV-16 E8 boolean AND E2 (16-E8 boolean AND E2) is independent of the major early promoter, P97, and is modulated by both specific splicing events and conserved cis elements in the upstream regulatory region in a manner that differs from transcriptional regulation of other early viral genes," researchers in the United States report.
"Mutations that disrupt the predicted 16-E8 boolean AND E2 message also increase initial HPV-16 plasmid amplification 8- to 15-fold and major early gene (P97) transcription 4- to 5-fold...
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Source: Gene Therapy Weekly (2008-12-25)
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