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Breast Cancer

Scientists at Duke University target breast cancer

Published in Gene Therapy Weekly, January 1st, 2009

According to a study from the United States, "Expression of estrogen-related receptor alpha (ERR(x) has recently been shown to carry negative prognostic significance in breast and ovarian cancers. The specific role of this orphan nuclear receptor in tumor growth and progression, however, is yet to be fully understood."

"The significant homology between estrogen receptor alpha (ER(alpha) and ERR alpha initially suggested that these receptors may have similar transcriptional targets. Using the well-characterized ER alpha-positive MCF-7 breast cancer cell line, we sought to gain a genome-wide picture of ER alpha-ERR alpha. cross-talk using an unbiased microarray approach....

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