Life Sciences
University of Rochester describes research in life sciences
Published in Gene Therapy Weekly, January 8th, 2009
Research findings, 'Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65,' are discussed in a new report. According to a study from the United States, "The U2 auxiliary factor large subunit (U2AF65) is an essential pre-mRNA splicing factor for the initial stages of spliceosome assembly. Tandem RNA recognition motifs (RRM). of U2AF65 recognize polypyrimidine tract signals adjacent to 3' splice sites."
"Despite the central importance of U2AF65 for splice site recognition, the relative arrangement of the U2AF65 RRMs and the energetic forces driving polypyrimidine tract recognition remain unknown. Here, the solution...
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Source: Gene Therapy Weekly (2009-01-08)
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