Cytokines

New cytokines research has been reported by X.G. Gu et al

Published in Gene Therapy Weekly, January 8th, 2009

According to recent research from the United States, "IL-17F, a member of the interleukin (IL)-17 cytokine family, most closely resembles IL-17A structurally. IL-17A is a potent stimulator of granulopoiesis; its expression is induced in response to microbial challenge."

"Although IL-17F is considered to be a weak IL-17A analog that is also mediating its effect via IL-17R, its exact role and in vivo functions are unknown. Our goal was to determine the in vivo activity of IL-17F on granulopoiesis as well as on release of granulopoiesis-stimulating downstream cytokines in mice and directly compare its effect to IL-17A. Murine IL-17A (mIL-17A) or IL-17F (mIL-17F) was...

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Source: Gene Therapy Weekly (2009-01-08)

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