Liposomes

Researchers from Zhejiang University describe findings in liposomes

Published in Gene Therapy Weekly, January 8th, 2009

According to a study from Hangzhou, People's Republic of China, "The objective of this study was to investigate the in vitro and in vivo influence of cationic liposomes on the tumor suppressive effect of antisense telomerase oligodeoxynucleotides to human cervical adenocarcinoma cells (HeLa). Antisense oligodeoxynucleotides (ASODN) against the human telomerase transcriptase (hTERT) served as telomerase inhibitors."

"The cholesterol derivative, 3 beta [N-(N ',N '-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol), was synthesized, and cationic liposomes (CL) were prepared using DC-Chol and dioleoylphosphatidylethanolamine (DOPE). The in vitro IC50 of the CL-ASODN...

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Source: Gene Therapy Weekly (2009-01-08)

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