Gene Therapy

Data on gene therapy reported by researchers at Seoul National University

Published in Gene Therapy Weekly, January 8th, 2009

"SCO4677 is one of a large number of similar genes in Streptomyces coelicolor that encode proteins with an HATPase_c domain resembling that of anti-sigma factors such as SpoIIAB of Bacillus subtilis. However, SCO4677 is not located close to genes likely to encode a cognate sigma or anti-anti-sigma factor," scientists writing in the Journal of Bacteriology report.

"SCO4677 was found to regulate antibiotic production and morphological differentiation, both of which were significantly enhanced by the deletion of SCO4677. Through protein-protein interaction screening of candidate sigma factor partners using the yeast two-hybrid system, SCO4677 protein was found to...

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Source: Gene Therapy Weekly (2009-01-08)

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