Gene Therapy

Reports outline gene therapy research from University of Edinburgh

Published in Gene Therapy Weekly, January 8th, 2009

"Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts of the survivin gene in chicken DT40 cells," scientists writing in the Journal of Cell Biology report.

"DT40 cells lacking Survivin die in interphase after failing to complete cytokinesis. However, these cells show normal sensitivity to the chemotherapeutic agent etoposide. Expression of Survivin mutants against a null background to reassess the role of several key residues reveals that DT40 cells can grow normally if their sole Survivin is missing a widely studied...

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Source: Gene Therapy Weekly (2009-01-08)

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