Cancer Gene Therapy
New cancer gene therapy study results from University of Texas described
Published in Gene Therapy Weekly, January 15th, 2009
According to recent research published in the journal Cancer Research, "Phospho-enriched protein in astrocytes (PEA-15) is a 15-kDa phosphoprotein that slows cell proliferation by binding to and sequestering extracellular signal-regulated kinase (ERK) in the cytoplasm, thereby inhibiting ERK-dependent transcription and proliferation. In previous studies of E1A human gene therapy for ovarian cancer, we discovered that PEA-15 induced the antitumor effect of E1A by sequestering activated ERK in the cytoplasm of cancer cells."
"Here, we investigated the role of PEA-15 in ovarian cancer tumorigenesis, the expression levels of PEA-15 in human ovarian cancer, and...
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Source: Gene Therapy Weekly (2009-01-15)
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