Cancer Vaccines

Research from C. Mennuni and co-authors provides new data about cancer vaccines

Published in Gene Therapy Weekly, January 29th, 2009

"The telomerase reverse transcriptase, TERT, is an attractive target for human cancer vaccination because its expression is reactivated in a conspicuous fraction of human tumors. Genetic vaccination with murine telomerase (mTERT) could break immune tolerance in different mouse strains and resulted in the induction of both CD4(+) and CD8(+) telomerase-specific T cells," scientists writing in the journal Cancer Research report.

"The mTERT-derived immunodominant epitopes recognized by CD8(+) T cells were further defined in these mouse strains and used to track immune responses. Antitumor efficacy of telomerase-based vaccination was investigated in two cancer models...

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Source: Gene Therapy Weekly (2009-01-29)

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