Adenocarcinoma

New findings from Xi'an Jiao Tong University in the area of adenocarcinoma described

Published in Gene Therapy Weekly, January 29th, 2009

According to recent research published in the journal BMC Cancer, "Mucin alterations are a common feature of esophageal neoplasia, and alterations in MUC2 mucin have been associated with tumor progression in the esophagus. Bile acids have been linked to esophageal adenocarcinoma and mucin secretion, but their effects on mucin gene expression in human esophageal adenocarcinoma cells is unknown."

"Human esophageal adenocarcinoma cells were treated 18 hours with 50-300 mc M deoxycholic acid, chenodeoxycholic acid, or taurocholic acid. MUC2 transcription was assayed using a MUC2 promoter reporter luciferase construct and MUC2 protein was assayed by Western blot...

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Source: Gene Therapy Weekly (2009-01-29)

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