Drug Development

Research on drug development described by S. Pons and colleagues

Published in Gene Therapy Weekly, January 29th, 2009

According to recent research from Paris, France, "The identification of the molecular mechanisms involved in nicotine addiction and its cognitive consequences is a worldwide priority for public health. Novel in vivo paradigms were developed to match this aim."

"Although the beta 2 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) has been shown to play a crucial role in mediating the reinforcement properties of nicotine, little is known about the contribution of the different alpha subunit partners of beta 2 (i.e., alpha 4 and alpha 6), the homo-pentameric alpha 7, and the brain areas other than the ventral tegmental area (VTA) involved in nicotine...

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Source: Gene Therapy Weekly (2009-01-29)

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