Gene Therapy
Reports summarize gene therapy study results from Kyoto University
Published in Gene Therapy Weekly, January 29th, 2009
According to recent research from Kyoto, Japan, "Rapid, large-volume injection, or so-called hydrodynamic injection, of naked plasmid DNA gives high transgene expression in mouse liver, and this method has been applied to liver-directed gene transfer in humans with slight modifications. To prove that injection-induced biological changes are involved in hydrodynamic injection-induced, high-level transgene expression in mouse liver, isotonic solutions were injected into mice that had received a hydrodynamic injection of plasmid DNA."
"Transgene expression in the liver was increased by such injections irrespective of the cDNA, promoter, and type of solution. This...
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Source: Gene Therapy Weekly (2009-01-29)
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