Melanoma

Study results from University of Wurzburg broaden understanding of melanoma

Published in Gene Therapy Weekly, January 29th, 2009

"Contrary to malignant melanoma, nevi are a benign form of melanocytic hyperproliferation. They are frequently observed as precursor lesions of melanoma, but they also feature biochemical markers of senescence," scientists in Wurzburg, Germany report.

"In particular, evidence for oncogene-induced melanocyte senescence as natural means to prevent tumorigenesis has been obtained in nevi with mutated B-Raf(V600E). Here, we demonstrate that strong oncogenic growth factor receptor signalling drives melanocytes into senescence, whereas weaker signals keep them in the proliferative state. Activation of oncogene-induced senescence also produces multinucleated giant cells, a...

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Source: Gene Therapy Weekly (2009-01-29)

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