Cancer Gene Therapy
Researchers from INSERM publish new studies and findings in the area of cancer gene therapy
Published in Gene Therapy Weekly, February 5th, 2009
According to a study from Nice, France, "Unmethylated CpG dinucleotides, present in bacterial DNA, are recognized in vertebrates via the Toll-like receptor 9 (TLR9) and are known to act as an anticancer agent by stimulating immune cells to induce a proinflammatory response. Although the effects of CpG-oligodeoxynucleotides (CpG-ODNs) in immune cells have been widely studied, little is known regarding their molecular effects in TLR9-positive tumor cells."
"To better understand the role of these bacterial motifs in cancer cells, we analyzed proteome modifications induced in TLR9-positive tumor cells in vitro and in vivo after CpG-ODN treatment in a rat colon carcinoma...
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Source: Gene Therapy Weekly (2009-02-05)
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