Gene Therapy
Findings from M.D.C. Molina and co-authors broaden understanding of gene therapy
Published in Gene Therapy Weekly, February 5th, 2009
According to recent research from the United States, "It has been shown that degradation of lipid/DNA complexes (lipoplexes) continues in the dried state during storage. The goal of this study was to evaluate the ability of various strategies to minimize the formation of reactive oxygen species (ROS) in lyophilized lipoplexes during storage, including metal removal from reagents, air displacement, and fortification with chelator/antioxidant agents."
"Formulations containing individual chelator (DTPA) and antioxidants (L-methionine or alpha-tocopherol), or in combination, were subjected to lyophilization. Accelerated storage conditions were investigated and...
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Source: Gene Therapy Weekly (2009-02-05)
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