RNA Research

Researchers at University of Toronto have published new data on RNA research

Published in Gene Therapy Weekly, February 12th, 2009

A new study, 'NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity,' is now available. "Clinical use of retinoic acids (RA) is hindered by toxicity possibly related to oxidative stress. Recently, RA at relatively low concentrations was shown to inhibit NRF2 and the expression of its target antioxidative genes," investigators in Toronto, Canada report.

"This raises the possibility that RA toxicity may result from cellular inability to cope with resultant oxidative stress. Using in vitro cell and in vivo mouse models, we report that RA, specifically all-trans-RA (atRA) at concentrations implicated in toxicity, can activate NRF2 and induce NRF2 target...

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Source: Gene Therapy Weekly (2009-02-12)

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