Antibiotics

Reports from D. Shu and co-researchers add new data to research in antibiotics

Published in Gene Therapy Weekly, February 12th, 2009

"Two-component system AfsQ1-Q2 of Streptomyces coelicolor was identified previously for its ability to stimulate actinorhodin (ACT) and undecylprodigiosin (RED) production in Streptomyces lividans. However, disruption of either afsQ1 or afsQ2 in S. coelicolor led to no detectable changes in secondary metabolite formation or morphogenesis," researchers in Shanghai, People's Republic of China report.

"In this study, we reported that, when cultivated on defined minimal medium (MM) with glutamate as the sole nitrogen source, the afsQ mutant exhibited significantly decreased ACT, RED, and calcium-dependent antibiotic (CDA) production and rapid growth of aerial mycelium. In...

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Source: Gene Therapy Weekly (2009-02-12)

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