Psoriasis
Reports on psoriasis findings from University of Munich provide new insights
Published in Gene Therapy Weekly, February 12th, 2009
"Cathelicidin is strongly expressed in lesional skin in psoriasis and may play an important role as both an antimicrobial peptide and as an autoinflammatory mediator in this chronic skin disease. The mechanism of increased cathelicidin in psoriatic keratinocytes is not known, but recent observations have found that psoriasis has abundant Th17 cells that produce IL-17A and IL-22," scientists writing in the Journal of Immunology report.
"We found that human keratinocytes stimulated with supernatants from T cells isolated from lesional psoriatic skin increased expression of cathelicidin when stimulated in the presence of 1,25-dihydroxyvitamin D-3 (1,25D(3)). This...
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Source: Gene Therapy Weekly (2009-02-12)
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