Cancer
Institute of Genetics and Developmental Biology details research in cancer
Published in Gene Therapy Weekly, February 19th, 2009
New investigation results, 'Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway,' are detailed in a study published in Oncogene. "xCT, the functional subunit of the cystine/glutamate transporter xc-system, plays a critical role in the maintenance of intracellular glutathione and redox balance. Disruption of xCT significantly inhibits the growth of a variety of carcinomas, including lymphoma, glioma, prostate and breast cancer," investigators in Beijing, People's Republic of China report.
"However, the role of xCT in tumor metastasis remains largely unknown. In this study, both xCT(+/+) and xCT(-/-) melanocytes were used to...
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Source: Gene Therapy Weekly (2009-02-19)
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