Enzyme Research

Reports summarize enzyme research study results from University of Central Lancashire

Published in Gene Therapy Weekly, February 19th, 2009

"Previously, we demonstrated that demethylation with 5-Aza-2'-deoxycytidine (5azadC) resulted in reduced levels of telomerase that led to telomere shortening, enhanced MGMT expression and enhanced chemosensitivity. Although the results were encouraging, the fact that 5azadC is highly toxic and nonspecific, thus is not favored as a therapeutic molecule," scientists writing in the journal Oligonucleotides report.

"The aim of this research is to downregulate the DNA methyltransferase (DNMT1) gene using three sets of double-stranded RNA oligos designed to align different regions of DNMT1 sequence. Results showed the small-interfering RNA (siRNA) 1 and 3 demonstrated...

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Source: Gene Therapy Weekly (2009-02-19)

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