Colon Cancer

New colon cancer research reported from U. Stein and co-authors

Published in Gene Therapy Weekly, February 26th, 2009

According to a study from Berlin, Germany, "We identified a previously undescribed gene associated with colon cancer by genome-wide expression analysis in primary and metastatic carcinomas: metastasis-associated in colon cancer-1, MACC1. MACC1 expression in tumor specimens is an independent prognostic indicator of metastasis formation and metastasis- free survival."

"We show that the gene encoding the hepatocyte growth factor (HGF) receptor, MET, is a transcriptional target of MACC1. MACC1 promotes proliferation, invasion and HGF-induced scattering of colon cancer cells in cell culture and tumor growth and metastasis in mouse models. These phenotypes are lost in cells...

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Source: Gene Therapy Weekly (2009-02-26)

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