B-Cell Lymphoma

New findings from Akita University, Medical Department in the area of B-cell lymphoma described

Published in Gene Therapy Weekly, February 26th, 2009

"Aberrant overexpression of the miR-17-92 polycistron is strongly associated with B-cell lymphomagenesis. Recent studies have shown that miR-17-92 down-regulates the proapoptotic protein Bim, leading to overexpression of Bcl2, which likely plays a key role in lymphomagenesis," scientists in Hondo, Japan report.

"However, the fact that Jeko-1 cells derived from mantle cell lymphoma exhibit both homozygous deletion of BIM and overexpression of miR-17-92 suggests other targets are also involved in B-cell lymphomagenesis. To identify essential target(s) of miR-17-92 in lymphomagenesis, we first transfected miR17-92 into 2 genetically distinct B-cell lymphoma cell lines:...

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Source: Gene Therapy Weekly (2009-02-26)

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