Gene Therapy

Reports on gene therapy findings from University of Colorado provide new insights

Published in Gene Therapy Weekly, March 5th, 2009

"Therapeutic benefit has been reported to result from intrathecal (i.t.) injection of transgene vectors, including naked DNA. However, most studies using naked DNA have measured only the transgene expression of intracellular proteins," researchers in the United States report.

"Here we demonstrate that i.t. injection of naked DNA can result in long-term expression of secreted proteins. Plasmids expressing either secreted alkaline phosphatase (SEAP) or human interleukin-10 (hIL-10) were injected into the i.t. space in rats, and transgene products were repeatedly measured in the cerebrospinal fluid (CSF). Both SEAP and hIL-10 were maximal at 1 and 2 days after the...

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Source: Gene Therapy Weekly (2009-03-05)

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