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Antisense Technology

Study findings on antisense technology are outlined in reports from T.J. Doran and colleagues

Published in Gene Therapy Weekly, March 12th, 2009

According to a study from the United States, "Microwave (MW) energy consists of electric and magnetic fields and is able to penetrate deep into biological materials. We investigated the effect of MW ( 2450 MHz) irradiation on gene delivery in cultured mouse myoblasts and observed enhanced transgene expression."

"This effect is, however, highly variable and critically dependent on the power levels, duration and cycle conditions of MW exposure. MW irradiation greatly enhances delivery of 2' O methyl-phosphorothioate antisense oligonucleotide (AON) targeting mouse dystrophin exon 23 and induces specific exon skipping in cultured myoblasts. Effective delivery of AON by MW...

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