Life Sciences

Study results from Vrije University, Medical Department broaden understanding of life sciences

Published in Gene Therapy Weekly, March 12th, 2009

According to recent research published in the Journal of Immunology, "A20 is a zinc finger protein with ubiquitin-modifying activity. A20 has been described as negatively regulating signaling induced by the TNF receptor and TLR family in a number of cell types, including mouse bone marrow-derived dendritic cells (DiCs)."

"However, the expression and effect of A20 in activated human monocyte-derived DCs have not been previously evaluated. We report that DCs activated with the TLR3 ligand poly(I:C) up-regulate A20. Down-regulating A20 demonstrated its role in the functional activation of DCs. A20 down-regulated DCs showed higher activation of the transcription...

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Source: Gene Therapy Weekly (2009-03-12)

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