RNA Libraries

Studies from McGill University update current data on RNA libraries

Published in Gene Therapy Weekly, March 12th, 2009

According to a study from Montreal, Canada, "Use of highly potent small interfering RNAs (siRNAs) can substantially reduce dose-dependent cytotoxic and off-target effects. We developed a genetic forward approach by fusing the cytosine deaminase gene with targets for the robust identification of highly potent siRNAs from RNA interference (RNAi) libraries that were directly delivered into cells via bacterial invasion."

"We demonstrated that two simple drug selection cycles performed conveniently in a single container predominately enriched two siRNAs targets the MVP gene (siMVP) and one siRNA targets the egfp gene (siEGFP) in surviving cells and these proved to be the...

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Source: Gene Therapy Weekly (2009-03-12)

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