Schizophrenia
Research from University of Sheffield broadens understanding of schizophrenia
Published in Gene Therapy Weekly, March 19th, 2009
"Schizophrenia may arise from subtle abnormalities in brain development due to alterations in the functions of candidate susceptibility genes such as Disrupted-in-schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1). To provide novel insights into the functions of DISC1 in brain development, we mapped the expression of zebrafish disc1 and set out to characterize its role in early embryonic development using morpholino antisense methods," scientists writing in the journal Human Molecular Genetics report.
"These studies revealed a critical requirement for disc1 in oligodendrocyte development by promoting specification of olig2-positive cells in the hindbrain and other...
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Source: Gene Therapy Weekly (2009-03-19)
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