Bioengineering

Research reports on bioengineering from University of Toronto provide new insights

Published in Gene Therapy Weekly, March 26th, 2009

According to recent research from Toronto, Canada, "Systematic functional genomics approaches were used to map a network centered on the small ubiquitin-related modifier (SUMO) system. Over 250 physical interactions were identified using the SUMO protein as bait in affinity purification-mass spectrometry and yeast two-hybrid screens."

"More than 500 genes and 1400 synthetic genetic interactions were mapped by synthetic genetic array (SGA) analysis using eight different SUMO pathway query genes. The resultant global SUMO network highlights its role in 15 major biological processes and better defines functional relationships between the different components of the SUMO...

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Source: Gene Therapy Weekly (2009-03-26)

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