Gene Therapy

Studies from Kyushu University provide new data on gene therapy

Published in Gene Therapy Weekly, April 2nd, 2009

According to a study from Fukuoka, Japan, "A cationic peptide, Td3701, which was derived from factor VIII that has affinity with phosphatidylserine (PS), showed efficient transfection ability for cells that express PS on the cell surface. PS is exposed on tumor cell surfaces therefore we have focused on PS as the target molecule for tumor specific gene delivery."

"In this article, to improve transfection efficiency and specificity in targeting tumor cells, some amino acid residues of Td3701 were replaced. The resulting peptide, Td3717, shows higher transfection efficiency (more than 30 times that of Td3701). The transfection efficiency was dependent on the amount of PS...

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Source: Gene Therapy Weekly (2009-04-02)

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