Life Sciences

Recent studies by M. Honda and co-authors add new data to life sciences findings

Published in Gene Therapy Weekly, April 9th, 2009

According to recent research from Tokyo, Japan, "The precise role of delta-sarcoglycan (SG) that is constitutively expressed in skeletal muscle cells and may serve for maintaining the sarcolemmal integrity has not been identified. The delta-SG protein is at first among SG complex."

"To specifically identify the role in C2C12 cells during the myogenesis, we screened several RNA interference (RNAi) candidates at first, and knocked down both levels of the mRNA and protein, employing adenovirus-mediated RNAi. We found no morphological alteration at both myoblast and myotube stages by suppression of delta-SG. The specific knockdown of delta-SG accompanied a concomitant...

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Source: Gene Therapy Weekly (2009-04-09)

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