Hepatitis B Virus
Reports from C.C. Chen and colleagues advance knowledge in hepatitis B virus
Published in Gene Therapy Weekly, April 16th, 2009
"Using a hepatitis B virus (HBV) transgenic mouse model, we previously showed that a single dose of double-stranded adeno-associated virus (dsAAV) vector serotype 8 carrying a small hairpin RNA (shRNA) effectively reduces HBV replication and gene expression, but the effect gradually decreases with time. In this report, we compared the anti-HBV RNA interference (RNAi) effect of dsAAV8 with those of dsAAV7 and dsAAV9, two other hepatotropic AAV vectors, and examined whether the sequential use of these heterologous AAV vectors could prolong the anti-HBV effect," scientists in Taipei, Taiwan report.
"Our results showed that shRNA delivered by each of the three dsAAV vectors...
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Source: Gene Therapy Weekly (2009-04-16)
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