Artificial Chromosomes

Data on artificial chromosomes reported by researchers at Tottori University

Published in Gene Therapy Weekly, April 16th, 2009

"Episomal vector with the capacity to deliver a large gene containing all the critical regulatory elements is ideal for gene therapy. Human artificial chromosomes ( HACs) have the capacity to deliver an extremely large genetic region to host cells without integration into the host genome, thus preventing possible insertional mutagenesis and genomic instability," investigators in Yonago, Japan report.

"Duchenne muscular dystrophy (DMD) is caused by mutation in the extremely large dystrophin gene (2.4 Mb). We herein report the development of a HAC vector containing the entire human dystrophin gene (DYS-HAC) that is stably maintained in mice and human immortalized...

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Source: Gene Therapy Weekly (2009-04-16)

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