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SARS

Research from Boston University in SARS provides new insights

Published in Gene Therapy Weekly, April 16th, 2009

According to a study from the United States, "In this study, infection of 293/ACE2 cells with severe acute respiratory syndrome coronavirus (SARS-CoV) activated several apoptosis-associated events, namely, cleavage of caspase-3, caspase-8, and poly(ADP-ribose) polymerase 1 (PARP), and chromatin condensation and the phosphorylation and hence inactivation of the eukaryotic translation initiation factor 2 alpha (eIF2 alpha). In addition, two of the three cellular eIF2 alpha kinases known to be virus induced, protein kinase R (PKR) and PKR-like endoplasmic reticulum kinase (PERK), were activated by SARS-CoV."

"The third kinase, general control nonderepressible-2 kinase...

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