Gene Therapy

Scientists at Kaohsiung Medical University publish new data on gene therapy

Published in Gene Therapy Weekly, April 23rd, 2009

According to recent research from Kaohsiung, Taiwan, "Polyelectrolyte complexes have been widely studied as gene carriers in recent years. In this study, poly (ethylene imine) was grafted onto chitosan (PEI-g-CHI) as a nonviral gene carrier in order to improve the water solubility as well as the inherent transfection efficiency of chitosan."

"We present a novel method to conjugate the amine or hydroxyl groups of chitosan (CHI) and the amine groups of PEI through opening the epoxide rings of ethylene glycol diglycidyl ether (EX-810), which also brings the merits as mentioned in PEGylation chemistry. The degree of substitution of PEI onto CHI was characterized by NMR. The...

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Source: Gene Therapy Weekly (2009-04-23)

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