Hyperglycemia

New hyperglycemia findings from L.L. Zhang and co-authors described

Published in Gene Therapy Weekly, April 23rd, 2009

"Chronic hyperglycemia contributes to pancreatic beta-cell dysfunction during the development of type 2 diabetes. Treatment of pancreatic beta-cells with prolonged high glucose concentrations has been shown to reduce insulin promoter activity and insulin gene expression," scientists in Toronto, Canada report.

"Here, we examined the effect of high glucose on endoplasmic reticulum (ER) stress pathway activation and insulin production in INS-1 832/13 pancreatic beta-cells. Treatment of cells with 25 mM glucose for 24-48 h decreased insulin mRNA and protein levels and reduced the proinsulin translation rate, which was accompanied by enhanced unfolded protein response...

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Source: Gene Therapy Weekly (2009-04-23)

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