Cardiology

New findings in cardiology described from Ohio State University

Published in Gene Therapy Weekly, April 23rd, 2009

According to a study from the United States, "ATP-sensitive potassium (K-ATP) channels in the heart are critical regulators of cellular excitability and action potentials during ischaemia. However, little is known about subcellular localization of these channels and their regulation."

"The present study was designed to explore the potential role of caveolae in the regulation of K-ATP channels in cardiac ventricular myocytes. Both adult and neonatal rat cardiomyocytes were used. Subcellular fractionation by density gradient centrifugation, western blotting, co-immunoprecipitation, and immunofluorescence confocal microscopy were employed in combination with whole-cell...

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Source: Gene Therapy Weekly (2009-04-23)

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