Stem Cell Research
New stem cell research findings from Cornell University, Medical Department described
Published in Gene Therapy Weekly, April 23rd, 2009
According to a study from the United States, "The conditional knockout of the small GTPase Cdc42 from neuroepithelial (NE) and radial glial (RG) cells in the mouse telencephalon has been shown to have a significant impact on brain development by causing these neural progenitor cells to detach from the apical/ventricular surface and to lose their cell identity. This has been attributed to the requirement for Cdc42 in establishing properapical/basal cell polarity and cell-cell adhesions."
"In the present study, we provide new insights into the role played by Cdc42 in the maintenance of neural progenitor cells, using the mouse embryonal carcinoma P19 cell line as a model...
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Source: Gene Therapy Weekly (2009-04-23)
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