Adenovirus

Data on adenovirus described by researchers at Wake Forest University, Medical Department

Published in Gene Therapy Weekly, April 30th, 2009

According to recent research from the United States, "Clinical trials have shown oncolytic adenoviruses to be tumor selective with minimal toxicity toward normal tissue. The virus ONYX-015, in which the gene encoding the early region 1B 55-kDa (E1B-55K) protein is deleted, has been most effective when used in combination with either chemotherapy or radiation therapy."

"Therefore, improving the oncolytic nature of tumor-selective adenoviruses remains an important objective for improving this form of cancer therapy. Cells infected during the G(1) phase of the cell cycle with the E1B-55K deletion mutant virus exhibit a reduced rate of viral late protein synthesis, produce...

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Source: Gene Therapy Weekly (2009-04-30)

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