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Angiogenesis

Research from S. Toffoli and colleagues provide new insights into angiogenesis

Published in Gene Therapy Weekly, May 7th, 2009

According to recent research published in the journal Angiogenesis, "The presence of hypoxia in tumor and its role in promoting angiogenesis are well-established. Recently, in addition to chronic hypoxia, cycling or intermittent hypoxia has also been demonstrated."

"However, its role in inducing new blood vessel formation is less clear. This work is aimed to investigate whether intermittent hypoxia can induce a pro-angiogenic phenotype in endothelial cells, in vitro. We studied changes in the expression of genes involved in inflammation and angiogenesis under intermittent and chronic hypoxia. We evidenced genes specifically expressed under intermittent hypoxia,...

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