Astrocytoma
Reports from University of Zurich advance knowledge in astrocytoma
Published in Gene Therapy Weekly, May 7th, 2009
"Early growth response-1 (EGR-1) is considered a central regulator in tumor cell proliferation, migration and angiogenesis and a promising candidate for gene therapy in human astrocytomas. However, conflicting data have been reported suggesting that both tumor promoting and anti-tumor activity of EGR-1 and its regulation, expression and prognostic significance still remain enigmatic," scientists writing in the journal Brain Pathology report.
"Our study explored EGR-1 expression and regulation in astrocytomas and its association with patient survival. As we detected two EGR-1 mRNA variants, one containing a N-methyl-D-aspartate-receptor (NMDA-R) responsive...
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Source: Gene Therapy Weekly (2009-05-07)
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