Ovarian Cancer

Studies from Y.H. Huang and co-researchers update current data on ovarian cancer

Published in Gene Therapy Weekly, May 7th, 2009

According to a study from the United States, "Claudin-3 (CLDN3) is a tight junction protein that is overexpressed in 90% of ovarian tumors. Previous in vitro studies have indicated that CLDN3 overexpression promotes the migration, invasion, and survival of ovarian cancer cells."

"Here, we investigated the efficacy of lipidoid-formulated CLDN3 siRNA in 3 different ovarian cancer models. Intratumoral injection of lipidoid/ CLDN3 siRNA into OVCAR-3 xenografts resulted in dramatic silencing of CLDN3, significant reduction in cell proliferation, reduction in tumor growth, and a significant increase in the number of apoptotic cells. Intraperitoneal injection of...

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Source: Gene Therapy Weekly (2009-05-07)

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