Life Sciences

New findings in life sciences described from University of Edinburgh

Published in Gene Therapy Weekly, May 14th, 2009

"Reprogramming of somatic cells to pluripotency, thereby creating induced pluripotent stem (iPS) cells, promises to transform regenerative medicine. Most instances of direct reprogramming have been achieved by forced expression of defined factors using multiple viral vectors(1-7)," scientists in Scotland report.

"However, such iPS cells contain a large number of viral vector integrations(1,8), any one of which could cause unpredictable genetic dysfunction. Whereas c-Myc is dispensable for reprogramming(9,10), complete elimination of the other exogenous factors is also desired because ectopic expression of either Oct4 (also known as Pou5f1) or Klf4 can induce...

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Source: Gene Therapy Weekly (2009-05-14)

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