Published in Gene Therapy Weekly, May 14th, 2009
"However, such iPS cells contain a large number of viral vector integrations(1,8), any one of which could cause unpredictable genetic dysfunction. Whereas c-Myc is dispensable for reprogramming(9,10), complete elimination of the other exogenous factors is also desired because ectopic expression of either Oct4 (also known as Pou5f1) or Klf4 can induce...
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