West Nile Virus

Study findings on west nile virus are outlined in reports from University of Texas

Published in Gene Therapy Weekly, May 14th, 2009

According to recent research published in the journal Virology, "The lifecycle of intracellular pathogens, especially viruses, is intimately tied to the macromolecular synthetic processes of their host cell. In the case of positive-stranded RNA viruses, the ability to translate and, thus, replicate their infecting genome is dependent upon hijacking host proteins."

"To identify proteins that participate in West Nile virus (WNV) replication, we tested the ability of siRNAs designed to knock-down the expression of a large subset of human genes to interfere with replication of WNV replicons. Here we report that multiple siRNAs for proteasome subunits interfered with...

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Source: Gene Therapy Weekly (2009-05-14)

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