Gene Therapy
Study results from National University in the area of gene therapy published
Published in Gene Therapy Weekly, May 14th, 2009
According to recent research published in the Journal of Biomedical Materials Research Part a, "In this study, three cationic polyrotaxanes composed of multiple oligoethylenimine-grafted alpha-cyclodextrin rings threaded on a poly(ethylene oxide) chain have been synthesized and characterized, and investigated for gene delivery. All three cationic polyrotaxanes could efficiently compact pDNA into small nanoparticles, with diameters ranging from 100 to 200 nm."
"In both BHK-21 and MES-SA cell lines, the transfection efficiency mediated by the cationic polyrotaxanes were comparable or even higher than that of branched polyethylenimine (PET) with a molecular weight...
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Source: Gene Therapy Weekly (2009-05-14)
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