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Gene Therapy

New data from Mayo Clinic, Medical Department illuminate research in gene therapy

Published in Gene Therapy Weekly, May 21st, 2009

According to a study from the United States, "We injected lentiviral vectors into the eyes of live nonhuman primates to assess potential for glaucoma gene therapy. Anterior chambers of five cynomolgus monkeys were injected with green fluorescent protein (GFP)encoding feline immunodeficiency viral vectors."

"The monkeys were monitored for in vivo transgene expression and clinical parameters. Their eyes were harvested 2-15 months postinjection for tissue analyses. All seven eyes injected with 1.0-2.0x10(8) transducing units (TU) showed substantial GFP fluorescence in the trabecular meshwork (TM), which was observable even by goniophotographic monitoring for up to 15...

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