Macropinocytosis
Studies from University of Kentucky update current data on macropinocytosis
Published in Gene Therapy Weekly, May 21st, 2009
According to recent research from the United States, "We previously reported that LDL modified by group V secretory phospholipase A(2) (GV-LDL) promotes macrophage foam cell formation through a mechanism independent of scavenger receptors SR-A and CD36, and dependent on cellular proteoglycans. This study investigates the role of syndecans, a family of cell surface proteoglycans known to mediate endocytosis through macropinocytosis, in macrophage uptake of GV-LDL."
"LY 294002, a phosphatidylinositol 3-kinase inhibitor, significantly reduced internalization of I-125-labeled GV-LDL in J-774 macrophages, consistent with a macropinocytic uptake pathway. Using small,...
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Source: Gene Therapy Weekly (2009-05-21)
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