Gene Therapy
Research from M.F.M. Mustapa and co-authors yields new data on gene therapy
Published in Gene Therapy Weekly, May 28th, 2009
"Recent research in the field of nonviral gene delivery vectors has focused on preparing nanoparticles that are stabilized by the incorporation of a PEG coating and where one of the vector components is also cleavable. Here,we describe the synthesis, formulation, transfection properties, and biophysical studies of a PEG-stabilized ternary lipopolyplex vector in which, for the first time, both the lipid and peptide components are designed to be cleaved once the vector has been internalized," scientists writing in the journal Bioconjugate Chemistry report.
"A series of cationic lipids, bearing short tri- or hexaethylene glycol groups, attached to the headgroup via...
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Source: Gene Therapy Weekly (2009-05-28)
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