Breast Cancer
Reports on breast cancer findings from Baylor College of Medicine, College of Medicine provide new insights
Published in Gene Therapy Weekly, May 28th, 2009
According to a study from the United States, "Each of the three members of the p160 steroid receptor coactivator (SRC) family of coactivators (SRC-1, SRC-2 and SRC-3) stimulates estrogen receptor (ER)-alpha function in trans-activation assays. Consequently, we sought to elucidate their contributions to the ER-regulated processes of cell proliferation, apoptosis, and the expression of ER alpha target genes in MCF-7 breast cancer cells."
"The small interfering RNA depletion of SRC-2 or SRC-3 but not SRC-1 inhibited growth of MCF-7 cells, and this was reflected in decreased cell cycle progression and increased apoptosis in SRC-2-or SRC-3-depleted cells as well as a...
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Source: Gene Therapy Weekly (2009-05-28)
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