Cancer

Findings from University of Texas provide new insights into cancer

Published in Gene Therapy Weekly, May 28th, 2009

"MDM2 belongs to a class of ring-finger domain - containing ubiquitin ligases that mediate the proteasomal degradation of numerous proteins, including themselves. Arguably, the most important substrate of MDM2 is p53, which controls cell cycle progression and apoptosis," scientists writing in the journal Molecular Cancer Therapeutics report.

"MDM2 and p53 are parts of a feedback regulatory loop whose perturbations are often present in cancer and are targets for anticancer drug development. We found that the natural product, small-molecule anti-inflammatory agent parthenolide (PN), which is actively being investigated as a potential therapeutic for many human...

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Source: Gene Therapy Weekly (2009-05-28)

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