Cancer Gene Therapy
New cancer gene therapy findings from University of Saskatchewan described
Published in Gene Therapy Weekly, June 4th, 2009
According to recent research from Saskatoon, Canada, "Recombinant adenoviral vectors (AdVTNF-alpha) expressing alpha tumor necrosis factor (TNF-alpha) under control of cytomegalovirus (CMV) promoter have been used in cancer gene therapy. To reduce its cytotoxicity, we constructed a recombinant AdV(TERT)mTNF-alpha expressing a mutant TNF-alpha (mTNF-alpha) with mutations at D142N and A144R under control of human telomerase reverse transcriptase ( hTERT) promoter for treatment of well-established ovalbumin (OVA)-expressing murine B16 melanoma (BL6-10(OVA)) (6mm in diameter)."
"We demonstrated that the mTNF-alpha with mutations at D142N and A144R has less in vitro...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2009-06-04)
More Articles from Gene Therapy Weekly
- Autoimmune Disease
Researchers from University of Rochester report recent findings in autoimmune disease - Autoimmune Lymphoproliferative Syndrome
Investigators at National Institutes of Health have published new data on autoimmune lymphoproliferative syndrome - Bioengineering
Investigators at University of Maryland have published new data on bioengineering - Cancer Gene Therapy
Research from Central South University has provided new information about cancer gene therapy - Cervical Cancer
Research on cervical cancer published by H. Chen et al - Colon Cancer
Reports outline colon cancer research from University of Hong Kong - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
